Roller Pump with Dynamic Occlusion Adjustment

ABSTRACT

A roller pump including a drive shaft, a motor, a roller head assembly, a stator housing, and an occlusion adjustment assembly. The drive shaft is coupled to the motor. The roller head assembly includes a hub, a slide body, and a roller. The hub is mounted to the drive shaft, and maintains the slide body and the roller. The stator housing forms a raceway receiving surface. The occlusion adjustment assembly includes an actuator knob, an actuating structure, and a ground shaft. The actuating structure interfaces with the slide body, and thus the roller, with rotation of the knob. The ground shaft supports the knob and is rotationally isolated from the drive shaft. A user and optionally a control system can adjust occlusion while the pump continuously delivers a fluid medium.

Background

The present disclosure relates to roller pumps used in medical devicesor systems (e.g., heart-lung bypass machine). More particularly, itrelates to roller pumps having occlusion adjustment features that can beactuated during operation of the pump.

Roller (or peristaltic) pumps have many uses in the medical field. Forexample, roller pumps are used during cardiovascular surgery tofacilitate circulation of blood between a patient and a heart-lungmachine. The operation of a roller pump is to pump fluid by positivedisplacement using revolving rollers that occlude flexible tubing. Inthe context of a heart-lung machine, several dedicated roller pumps arecommonly used as part of the perfusion circuit to pump the arterialcircuit (where a centrifugal pump is not used), vent, cardiotomysuction, and cardioplegia. Other common medical uses are the transfer ofblood between a patient and a kidney dialyzer, and intravenous (IV)feeding of IV solutions. Generally, roller pumps are simply structured,generate a constant flow, and use disposable tubing through which afluid medium is transferred.

Roller pumps generally comprise a pump drive and a pump head. The pumpdrive causes rotation of the pump head to pump a fluid medium. The pumphead comprises a pump stator and a pump rotor. The pump stator isessentially a chamber or housing having an inner circumferential surface(or “raceway”) against which one or more tubes are compressed by thepump rotor. The pump rotor, which is rotatable relative to the stator,is arranged in the pump stator in such a manner that the pump rotorengages tubing positioned in the pump stator with one or more rollers.Upon rotation of the pump rotor by a rotating shaft that is otherwisepart of the pump drive, the roller(s) compress the tubing against theinner circumferential surface of the pump stator as it is rolled alongthe tubing. The fluid medium contained in the tubing is then transportedin a direction of the pump rotor rotation.

It is important that roller pumps be adjustable. One way that rotorpumps are generally adjustable is with respect to the rate of rotationof the rotor, including the rollers. Most roller pumps have controlsthat allow a user to adjust and/or set the rotation rate. Another waythat roller pumps are generally adjustable is with respect to thedistance between the rollers and the inner circumferential surface ofthe stator. This parameter is often referred to as “occlusion” andreflects the degree to which the tubing is compressed or occludedbetween the rollers and the raceway surface. The degree or level ofocclusion increases as the rollers are moved into closer proximity withthe raceway surface. Varying the amount the rollers occlude or compressthe diameter of the tubing in the pump as they move affects the pumpingrate. The level of occlusion of the tubing also affects the amount ofsuction on the fluid medium. If the roller pump is used in certainportions of the anatomy, there may be limits on the amount of suctionthat can be applied safely to withdraw a fluid medium. An example ofsuch a use for a roller pump is connected to a heart vent line, wheretoo much suction could result in tissue damage. Additionally, thedistance between the rollers and the raceway may be adjusted toaccommodate differentially-sized (or quality) tubing. In summary, aperfusionist often desires to adjust occlusion to optimize competingcriteria such as blood hemolysis, tubing spatulation, flow ratecalculation accuracy, and to compensate for manufacturing variations intubing.

Conventional perfusion roller pumps typically incorporate an occlusionadjustment mechanism that allows the perfusionist to manually adjust theocclusion “setting” or level. Known occlusion adjustment mechanisms arerelatively simplistic, and require that the pump drive be deactivated(i.e., the roller pump is not pumping fluid) while the occlusion settingis adjusted. While viable, this approach can be quite time consuming andrequires that the pump be stopped every time the perfusionist wishes toadjust occlusion. Moreover, occlusion adjustment typically requires theperfusionist to adjust the distance between the rollers and the racewaywith one hand while holding a piece of tubing filled with a column ofliquid at a height of one meter above the pump head with the other handand determine when the column of liquid is dropping at a rate of 2.5centimeters per minute. This is both cumbersome and inconsistent.

In light of the above, a need exists for roller pumps, especially rollerpumps used in perfusion circuits, providing improved occlusionadjustment features.

SUMMARY

Some aspects in accordance with principles of the present disclosurerelate to a roller pump including a drive shaft, a motor, a rotorassembly, a stator housing, and an occlusion adjustment assembly. Thedrive shaft defines a central axis and is coupled to the motor. Themotor thus rotates the drive shaft about the central axis. The rotorassembly includes a hub, a slide body, and a roller. The hub is mountedto the drive shaft. The slide body is slidably connected to the hub suchthat the slide body rotates with rotation of the hub, but can be movedradially relative to the hub. The roller is rotatably coupled to theslide body opposite the drive shaft. The stator housing forms a racewayhaving an inner arcuate receiving surface. In this regard, the statorhousing is associated with the rotor assembly to define an occlusionzone between the roller and the receiving surface. The occlusionadjustment assembly slidably adjusts a radial position of the rollerrelative to the receiving surface, and includes an actuator knob, anactuating structure, and a ground shaft. The actuating structure isconnected to the knob. The ground shaft supports the actuator knobrelative to the drive shaft. In this regard, the actuating structureinterfaces with the slide body to selectively alter a radial position ofthe slide body relative to the central axis of the drive shaft (and thusrelative to the receiving surface) with rotation of the knob. Finally,the drive shaft and the ground shaft are rotationally isolated from oneanother. With this construction, roller pumps of the present disclosureallow a user to perform occlusion adjustment while the pump is otherwiseoperating to pump a fluid medium. In some embodiments, the occlusionadjustment assembly further includes a ring threadably coupled to theknob and longitudinally affixed to the cam structure such that rotationof the knob is translated to longitudinal movement of the cam structurevia the ring. In yet other embodiments, an occlusion shaft is co-axiallydisposed within a lumen of the ground shaft, with an end portion of theocclusion shaft extending beyond the ground shaft and acted upon by acartridge motor operable to effectuate occlusion adjustment via anelectronic controller. In related embodiments, the controller isprogrammed to prompt operation of the cartridge motor based on aperfusion circuit parameter such as line pressure, motor torque, flowrate and/or user input.

Other embodiments in accordance with principles of the presentdisclosure relate to a method operating a roller pump as part of aperfusion circuit. The method includes loading a tubing line of theperfusion circuit to the roller pump described above, with the tubingline being disposed against the raceway receiving surface. The motor isoperated to cause the slide body and roller to rotate relative to theso-loaded tubing line to effectuate pumping of a fluid medium throughthe tubing line. In this regard, the roller is located at a first radialposition relative to the receiving surface, thereby occluding the tubingline at a first level of occlusion. While continuing to operate themotor, the actuator knob is rotated to alter a radial location of theroller to a second radial position differing from the first radialposition so as to provide a second level of occlusion. In someembodiments, the roller pump further includes a cartridge motor linkedto the occlusion adjustment assembly, and a controller programmed toprompt operation of the cartridge motor. In these embodiments, themethod can further include receiving information at the controllerindicative of an operating parameter of the perfusion circuit. Thecontroller automatically prompts operation of the cartridge motor toeffectuate movement of the roller to a third radial position relative tothe receiving surface as a function of the received information withcontinuous operation of the motor.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a perspective view of a roller pump in accordance withprinciples of the present disclosure;

FIG. 2 is a longitudinal cross-sectional view of the roller pump of FIG.1;

FIG. 3 is a transverse cross-sectional view of the roller pump of FIG.1;

FIG. 4 is an exploded, perspective view of the roller pump of FIG. 1;

FIG. 5A is an enlarged view of a portion of the roller pump of FIG. 2;

FIG. 5B is an enlarged view of another portion of the roller pump ofFIG. 2;

FIG. 6 is a simplified top view of the roller pump of FIG. 1 andillustrating a pumping mode of operation;

FIG. 7 is a simplified top view of the roller pump of FIG. 1 andillustrating an occlusion adjustment mode of operation; and

FIG. 8 is a block diagram of a system including the roller pump of FIG.7.

DETAILED DESCRIPTION

One embodiment of a roller pump 20 in accordance with principles of thepresent disclosure is shown in FIG. 1. The roller pump 20 includes ahousing 22 maintaining various drive components (not shown, butdescribed in greater detail below), a roller head assembly 24, a statorframe 26, and an occlusion adjustment assembly 28 (referencedgenerally). Details on the various components are provided below. Ingeneral terms, the roller pump 20 is configured to maintain a length offlexible tubing 30 between the stator frame 26 and one or more rollers32 provided with the roller head assembly 24. Optionally, one or moretubing clamps 34 can be provided to retain the tubing 30 as desired.Regardless, the tubing 30 is pressed between the stator frame 26 and theroller(s) 32. With rotation of the roller head assembly 24 (via thedrive components within the housing 22), the roller(s) 32 travels alongthe tubing 30, thereby pushing a fluid medium through the tubing 30. Aradial position of the roller(s) 32 relative to the stator frame 26 isadjustable via operation of the occlusion adjustment assembly 28. Inthis regard, the occlusion adjustment assembly 28 is configured suchthat occlusion adjustment (i.e., changing the level or degree ofocclusion) can be performed while the roller head assembly 24 continuesto rotate (and thus while the roller pump 20 continues to pump fluid).The roller pump 20 can optionally include other features, such as theauxiliary mounting assembly 36 as shown (the optional auxiliary mountingassembly 36 is omitted from the remaining views).

Components of a drive assembly 38 maintained by the housing 22 are shownin FIG. 2 and include a motor 40 and a drive shaft 42. The motor 40 canassume various forms, for example a DC brushless and frameless motorincluding a rotor 44 and a stator 46. The drive shaft 42 is coupled tothe motor 40 such that operation of the motor 40 causes the drive shaft42 to rotate about a central axis A. The drive shaft 42 can be anelongated, rigid tube forming a central passageway or lumen 48 that isotherwise open at opposing first and second ends 50, 52 of the driveshaft 42. As used throughout this specification, reference to “radial”or “longitudinal” directions is relative to the central axis A.

Driven coupling between the motor 40 and the drive shaft 42 can beeffectuated in various manners, for example by a hub 54 that is rigidlyconnected to the rotor 44 and the drive shaft 42. Further, the driveassembly 38 can include additional features that effectuate stabilizedmounting of the motor 40 and the drive shaft 42 relative to othercomponents of the roller pump 20 (e.g., the stator frame 26 and theroller head assembly 24). For example, the housing 22 can include ordefine a motor housing section 56 that at least partially encloses themotor 40. Upper and lower main bearing units 58, 60 rotatably supportthe drive shaft 42. In some embodiments, a locking nut 62 is mounted tothe drive shaft 42 adjacent the lower main bearing unit 60, and a flange64 is formed by the drive shaft 42 at the upper main bearing unit 58 tolimit overt longitudinal movement of the drive shaft 42.

With reference to FIGS. 2-4, the roller head assembly 24 includes, insome constructions, a hub 70, one or more slide bodies 72 a, 72 b, oneor more of the rollers 32, and one or more optional biasing devices(e.g., springs) 74 a-74 d. The hub 70 is a generally cylindrical bodydefining a base wall 76, an outer wall 78 and a central post 80. One ormore slots 82 a, 82 b are formed through a radial thickness of the outerwall 78 and are sized to slidably receive a respective one of the slidebodies 72 a, 72 b. More particularly, the base wall 76 slidably supportsthe slide bodies 72 a, 72 b, and opposing side surfaces 84 (one of whichis fully visible in FIG. 4) defining the corresponding slot 82 a, 82 bbear against a side of the corresponding slide body 72 a, 72 b totransfer rotational movement of the hub 70 onto the slide bodies 72 a,72 b. Finally, the central post 80 is configured for mounting to thedrive shaft 42 adjacent the first end 50 and defines a guide face 86.

While the roller pump 20 is illustrated as including two of the slidebodies 72 a, 72 b, any other number, greater or lesser, is alsoacceptable. With the one embodiment shown, the slide bodies 72 a, 72 bare identical, such that the following description of the first slidebody 72 a applies equally to the second slide body 72 b. As shown inFIG. 3, the slide body 72 a defines a leading side 90 and a trailingside 92. A cutout 94 is formed at the leading side 90, and is sized andshaped to rotatably maintain one of the rollers 32. The trailing side 92forms a receiving face 96 (best shown in FIG. 2 and for the second slidebody 72 b in FIG. 4) configured to slidably interface with acorresponding component of the occlusion adjustment assembly 28 asdescribed below. Finally, the slide body 72 a can include variousfeatures that facilitate assembly with corresponding ones of the springs74 a-74 d. For example, the slide body 72 a can include opposing fingers98 projecting from the trailing side 92 and configured for attachment toan end of one of the springs 74 a-74 d.

Each of the slide bodies 72 a, 72 b rotatably maintains one of therollers 32. In this regard, and as identified for the roller 32associated with the first slide body 72 a in FIG. 2, the roller 32 canbe provided as part of a roller sub-assembly 100 that otherwise includesa pin 102 and roller bearing units 104. The roller bearing units 104rotatably connect the roller 32 with the pin 102. Further, the pin 102is configured for assembly to the leading side 90 of the slide body 72a. With this construction, then, the slide body 72 a maintains thecorresponding roller 32 at a fixed radial location relative to thetrailing side 92, and in particular the receiving face 96, such that theroller 32 moves radially relative to the central axis A with radialsliding movement of the slide body 72 a. Further, rotation of the hub 70(via rotation of the drive shaft 42) is transferred to the slide body 72a, 72 b, and thus to the corresponding rollers 32.

As best shown in FIG. 3, the springs 74 a-74 d can be identical, and areprovided in pairs with a corresponding one of the slide bodies 72 a-72b. Two of the springs 74 a, 74 b are assembled between the first slidebody 72 a and the outer wall 78. In particular, a first end of each ofthe springs 74 a, 74 b is coupled to a respective one of the slide bodyfingers 98, and an opposing, second end of each spring 74 a, 74 b ismounted to an interior face 106 of the outer wall 78. With thisconstruction, the springs 74 a-74 d preload the slide bodies 72 a, 72 btoward the central axis A for reasons made clear below.

As best shown in FIGS. 2 and 3, the stator frame 26 includes, in someembodiments, a base 110 and a flange portion 112. The base 110 is sizedand shaped to generally match a size and shape of the outer housing 22,and is configured for assembly to the motor housing section 56. Theflange 112 extends from the base 110 to define a raceway 114 having aninner arcuate receiving surface 116 against which the flexible tubing 30(FIG. 1) is disposed as described below.

With reference to FIG. 2, occlusion adjustment assembly 28 includes, insome embodiments, an actuator knob 120, an actuating structure 122, aground shaft 124, and an optional occlusion shaft 126. In general terms,the actuating structure 122 is connected with the knob 120 such thatrotation of the knob 120 effectuates movement the actuating structure122. Further, the actuating structure 122 interfaces with the slidebodies 72 a, 72 b so as to adjust a radial position of the slide bodies72 a, 72 b. The ground shaft 124 is rigidly connected to the motorhousing 56 (or other “ground” component that keeps the ground shaft 124stationary) and supports the knob 120 relative to the drive shaft 42 andthe roller head assembly 24 in a manner rotationally isolating the knob120 from the roller head assembly 24/drive shaft 42. The occlusion shaft126 is rigidly connected to the knob 120 and thus turns with rotation ofthe knob 120 (and vice-versa). As described below, the occlusion shaft126 couples the knob 120 to an optional occlusion cartridge motor 128.

Portions of the occlusion adjustment assembly 28 are shown in greaterdetail in FIG. 5A. As illustrated, in some embodiments, the knob 120forms or includes internal threads 130, and can be constructed of two ormore components, such as a plastic cap 132 over molded to a threadedinsert 134. With this approach, the molded cap 132 can define variousexterior surface features that facilitate ergonomic grasping or handlingby a user. Conversely, the threaded insert 134 can be formed of a metalor other structurally robust material that facilitates precise formationof the internal threads 130. Regardless of an exact construction, one ormore features are further provided to facilitate rotationally isolatedmounting or connection of the knob 120 with the ground shaft 124. Forexample, the knob 120 can form a bushing 136 configured for rotatableconnection to the ground shaft 124 via one or more actuator bearingunits 138 as described below. Finally, a pinned or other fixedconnection between the occlusion shaft 126 and the knob 120 can beprovided, such as at a bore 140 formed in the threaded insert 134.

The actuating structure 122 can be akin to a cam and includes, in someembodiments, a cam body 150 and a sleeve 152. The cam body 150 is sizedand shaped to interface with the slide bodies 72 a, 72 b, and the sleeve152 facilitates coupling with the actuator knob 120 (along with othercomponents described below).

In some embodiments, the cam body 150 is a ring having the wedge-likeshape as shown. More particularly, the cam body 150 forms or defines aguide surface 154 and a bearing surface 156. The guide surface 154defines an inner diameter of the cam body 150, and is sized to slidinglyabut the guide face 86 (FIG. 4) of the hub 70. The bearing surface 156extends in an angular fashion from the guide surface 154 at a leadingend 158 of the cam body 150. Stated otherwise, the cam body 150 has anincreasing radial thickness from the leading end 158 to a trailing end160, with the bearing surface 156 being substantially flat. Asillustrated, the cam body 150 and the slide bodies 72 a, 72 b areconstructed such that upon final assembly, an angle of extension of theslide body receiving face 96 corresponds with that of the cam bodybearing surface 156. Upon final assembly, as the cam body 150 is causedto move in a longitudinal direction (relative to the central axis A),the bearing surface 156 slides along the receiving face 96 of thecorresponding slide body 72 a, 72 b. The actuating structure 122 canassume other formats configured to slidably adjust or move the slidebodies 72 a, 72 b. For example, the cam interface provided by thelongitudinally moving wedge body 150 can be replaced with ascissors-type mechanism.

The sleeve 152 can assume various forms commensurate with othercomponents of the occlusion adjustment assembly 28 described below. Ingeneral terms, the sleeve 152 is attached to, and extends from, thetrailing end 160 of the cam body 150, and forms a shelf 162 or similarstructure.

The actuating structure 122 can be connected to the actuator knob 120 invarious fashions. In some embodiments, the occlusion adjustment assembly28 includes a ring 170 and an occlusion bearing unit 172. The ring 170forms or defines an outer region 180, an intermediate region 182, and aninner region 184. The outer region 180 defines exterior threads 186. Theexterior threads 186 correspond with the internal threads 130 of theactuator knob 120 such that the exterior threads 186 threadably engagethe internal threads 130. The intermediate region 182 forms a ledge 188for mounting to the occlusion bearing unit 172, as well as an annularslot 190 sized and shaped for clearance about a portion of the sleeve152. Finally, the inner region 184 projects radially inwardly from theintermediate region 182, and terminates at an inner diameter 192 of thering 170. As generally reflected in FIG. 5A, the inner region 184further forms a radial notch 194 sized to slidably receive acorresponding segment of the ground shaft 124 as described below.

The occlusion bearing unit 172 rotationally connects the actuatingstructure 122 and the ring 170, and is mounted at the actuatingstructure shelf 162 and the ring ledge 188. With this construction,rotation of the actuator knob 120 is transferred to the ring 170 at thethreaded interface 130/186, and causes the ring 170 to move in alongitudinal direction. This longitudinal movement or force istransferred to the actuating structure 122 via the occlusion bearingunit 172. Thus, the cam body 150 moves longitudinally with rotation ofthe actuator knob 120. For reasons made clear below, the occlusionbearing unit 172, while establishing a rigid longitudinal connectionbetween the actuating structure 122 and the ring 170, allows theactuating structure 122 to freely rotate relative to the ring 170. Inother words, while rotation of the knob 120 effectuates longitudinal (orother) movement of the actuating structure 122, radial movement isde-coupled through the occlusion bearing unit 172

The ground shaft 124 is concentrically arranged with the drive shaft 42(i.e., upon final assembly, the drive shaft 42 and the ground shaft 124share the same, common central axis A). With this but one acceptableconstruction of FIG. 5A, the ground shaft 124 is sized to be disposedco-axially within the lumen 48 of the drive shaft 42. In this regard,the ground shaft 124 defines opposing, first and second end portions200, 202 (the second end portion 202 shown in FIG. 2). The ground shaft124 is sized and shaped such that, upon final assembly, the first endportion 200 extends beyond the first end 50 of the drive shaft 42, andthe second end portion 202 extends beyond the second end 52. Further,the first end portion 200 forms a radial key 204. The key 204 is sizedto be slidably received within the notch 194 of the ring 170. Aninterface between the key 204 and the notch 194 is such that the groundshaft 124 resists rotation of the ring 170 (where the ground shaft 124is held stationary) via the notch 194/key 204 interface. However, thekey 204 permits the ring 170 to move or slide longitudinally relative tothe ground shaft 124. Thus, any rotational force imparted onto the ring170 with rotation of the knob 120 is offset or resisted by the groundshaft 124. The ring 170/ground shaft 124 interface ensures that rotationof the knob 120 translates into substantially only longitudinal movementof the ring 170.

A secondary bearing unit 210 is mounted between the drive shaft 42 andthe ground shaft 124. The secondary bearing unit 210 longitudinallysupports the ground shaft 124 relative to the drive shaft 42 in a mannerpermitting the drive shaft 42 to rotate relative to the ground shaft 124(and vice-versa). Stated otherwise, the drive shaft 42 and the groundshaft 124 are rotationally isolated from one another.

In some embodiments, the occlusion adjustment assembly 28 furtherincludes one or more components that provide a user with a physicaland/or audible indication of the extent of knob rotation. For example, aspring finger 212 can be assembled to the knob 120, and arranged togenerate an audible, optionally tactile, “click” or noise with everyrevolution, or every segment of revolution, of the knob 120. Forexample, the spring finger 212 can be arranged to generate a tactile“click” at every 7.2 degree of knob rotation. A variety of otherarrangements are also acceptable. In some embodiments, the rotationindication generated by the spring finger 212 correlates with apre-determined amount or level of occlusion adjustment (e.g., 0.0005inch occlusion adjustment) as described below.

As shown in FIG. 5B, the ground shaft 124 is further supported at thesecond end portion 202. For example, in some embodiments, intermediateframework 214 is fixed to, and extends from, the motor housing section56, and provides a threaded surface 216 that threadably engages thesecond end portion 202. A maximum range of movement between the twocomponents can be limited by a jam nut assembly 218. Other mountingconstructions are also envisioned, including those that rigidly retainthe ground shaft 124 relative to the motor housing section 56.Regardless, the ground shaft 124 is concentrically maintained relativeto the drive shaft 42, and does not longitudinally or rotationally moverelative to the motor housing section 56.

Returning to FIG. 2, where provided, the occlusion shaft 126 isconcentrically disposed within the ground shaft 124, and defines a firstend section 230 and an opposing second end section 232. The first endsection 230 is fixed to the knob 120 as described above. Thus, theocclusion shaft 126 effectively serves as an extension of the knob 120.The occlusion shaft 126 has a length sufficient such that the second endsection 232 projects beyond the second end portion 202 of the groundshaft 124. The second end section 232 of the occlusion shaft 126 iscoupled to the optional cartridge motor 128 with embodiments in whichthe pump 20 is configured to provide automated occlusion adjustment asdescribed below.

Assembly of the roller pump 20 includes the motor 40 being disposedwithin the motor housing section 56, and the motor housing section 56mounted to the stator frame 26. The drive shaft 42 is coupled to themotor 44. The roller head assembly 24, and in particular the hub 70, ismounted to the drive shaft 42. The ground shaft 124 is concentricallyarranged within the drive shaft 42, and the cam body 150 placed into anabutting relationship with the hub 70 and the slide bodies 72 a, 72 b.The actuator knob 120 is connected to the ground shaft 124 in arotationally isolated fashion. Further, the actuator knob 120 is linkedto the actuating structure 122 via the ring 170 (FIG. 5A) and theocclusion bearing unit 172 (FIG. 5A). The motor housing section 56 ismounted to other portions of the housing 22 (e.g., the intermediateframework 214, a bottom cup 240, etc.). Where provided, the occlusionshaft 126 is disposed within the ground shaft 124, linking the knob 120with the cartridge motor 128. As generally reflected in FIG. 2, uponfinal assembly, a radial distance between the rollers 32 and the racewayreceiving surface 116 is directly related to the radial location of thecorresponding slide body 72 a, 72 b relative to the central axis A. Theslide body 72 a, 72 b radial position, in turn, is dictated by theocclusion adjustment assembly 28, and in particular by a longitudinalarrangement of the cam body 150 (identified in FIG. 5A) as otherwiseselected through operation of the knob 120. Notably, the knob 120 isrotationally isolated from the drive shaft 42 for reasons made clearbelow.

During use, the roller pump 20 provides pumping and occlusion adjustmentmodes of operation, and is useful, for example, as part of a perfusioncircuit. Initially, and as shown in FIGS. 1 and 6, a length of theflexible tubing 30 through which the fluid medium is to be pumped isloaded to the roller pump 20. In particular, the tubing 30 is disposedagainst the receiving surface 116 of the stator raceway 114, and can beheld in place by the optional tubing clamps 34. Further, the flexibletubing 30 is pinched against the receiving surface 116 by the rollers32. In effect, an occlusion zone or distance 250 is established betweeneach of the rollers 32 and the receiving surface 116, with the distance(or “level” of occlusion) 250 being adjustable as described below.

In the pumping mode of operation, and with additional reference to FIG.2, the motor 40 is operated to rotate the drive shaft 42. Rotation ofthe drive shaft 42 is transferred to the hub 70, and thus to the slidebodies 72 a, 72 b and the rollers 32 carried thereby. FIG. 6 reflectsthe roller head assembly 24 (FIG. 2) rotating in a clockwise direction;as the slide bodies 72 a, 72 b are caused to rotate relative to thetubing 30, the occlusion zone 250 effectuated by the rollers 32similarly moves or progresses along the tubing 30 (it being understoodthat the rollers 32 freely rotate relative to the corresponding slidebody 72 a, 72 b about their axis of symmetry). As a result, a fluidmedium is caused to progressively move or “pump” through the tubing 30,with the rotational direction of the roller head assembly 24 effectivelyestablishing a fluid inlet 260 and a fluid outlet 262.

With specific reference to FIG. 5A, rotation of the drive shaft42/roller head assembly 24 is not transferred to or otherwise impartedupon the ground shaft 124 or the actuator knob 120. That is to say, theknob 120 and the ground shaft 124 are rotationally isolated from theroller head assembly 24 and the drive shaft 42. However, the actuatingstructure 122 will rotate with rotation of the roller head assembly 24via the wedged interface of the cam body 150 between the hub 70 and theslide bodies 72 a, 72 b. The occlusion bearing unit 172 isolatesrotational movement of the actuating structure 122 from the ring 170,and thus from the actuator knob 120 and the ground shaft 124. Thesprings 74 a-74 d (FIG. 3) maintain a constant pressure between the cambody 150 and the corresponding slide bodies 72 a, 72 b.

The level or amount of occlusion (i.e., the radial distance 250 (FIG. 6)between the rollers 32 and raceway receiving surface 116) can be changedin the occlusion adjustment mode of operation. With reference to FIGS.5A and 7, occlusion adjustment is effectuated by a user rotating theactuator knob 120. Knob rotation is translated into longitudinalmovement of the ring 170 via the threaded interface 134, 186. Dependingupon the direction of knob rotation, the ring 170 is thus caused to movelongitudinally toward or away from the slide bodies 72 a, 72 b. Due tothe longitudinally fixed (but rotationally isolated) connection providedby the occlusion bearing unit 172 between the ring 170 and the camstructure 122 (and in particular the sleeve 152), the actuatingstructure 122 experiences an identical longitudinal movement withlongitudinal movement of the ring 170. Thus, with rotation of theactuator knob 120, the cam body 150 moves longitudinally relative to theslide bodies 72 a, 72 b. The camming interface between the cam body 150and the slide bodies 72 a, 72 b, in turn, affects a change in a radialposition of the slide bodies 72 a, 72 b relative to the central axis A.

As a point of reference, in the view of FIG. 5A, the roller pump 20 isarranged at an intermediate occlusion state, with the ring 170, and thusthe cam body 150, at an intermediate longitudinal distance away from theslide bodies 72 a, 72 b. As reflected in FIG. 7, with rotation of theknob 120 (e.g., clockwise in FIG. 7), the slide bodies 72 a, 72 b, andthus the rollers 32 carried thereby, are forced radially outwardly,thereby decreasing the occlusion zone or distance 250 associated witheach of the rollers 32. With further reference to FIG. 5A, rotation ofthe knob 120 causes the ring 170, and thus the cam body 150, to movelongitudinally toward the slide bodies 72 a, 72 b (downwardly relativeto the orientation of FIG. 5A), with the camming interface between thecam body 150 and the slide bodies 72 a, 72 b forcing the slide bodies 72a, 72 b (and the rollers 32 carried thereby) radially outwardly relativeto the central axis A. A maximum occlusion state is achieved once thecam body bearing surface 156 is longitudinally beyond (e.g., below) theslide body receiving surface 96. Rotation of the knob 120 is an oppositedirection causes the ring 170, and thus the cam body 150, to movelongitudinally away from (upwardly) the slide bodies 72 a, 72 b. Thecamming interface force applied by the bearing surface 156 on thereceiving surface 96 is thereby reduced. The springs 74 a-74 d (FIG. 3),in turn, bias the corresponding slide body 72 a, 72 b radially inwardly.In a minimum occlusion state, the slide bodies 72 a, 72 b contact thehub post 80.

Any level or amount of occlusion between the minimum occlusion state andthe maximum occlusion state can be selected or effectuated by a user.Notably, occlusion adjustment steps can be performed while the rollerpump 20 is simultaneously and continuously operating to pump a fluidmedium. By rotationally isolating the drive shaft 42 from the actuatorknob 120 and the ring 170 via the concentrically arranged ground shaft124, the roller pump 20 eliminates the need for the user (e.g.,perfusionist) to stop the pump every time occlusion adjustment isdesired. Commensurate with this explanation, methods of operating aroller pump as part of a perfusion circuit in accordance with principlesof the present disclosure include loading the flexible tubing 30(FIG. 1) to the roller pump 20, operating the motor 40 to cause a fluidmedium to be pumped through the tubing 30 with the roller pump 20arranged at a first level of occlusion, and adjusting the level ofocclusion to a second, different level while the motor 40 continues tooperate (and the fluid medium continues to be pumped).

In addition to facilitating manual occlusion adjustment, the roller pump20 optionally further provides for automated occlusion adjustment. Forexample, FIGS. 2 and 5B illustrates coupling of the optional occlusionshaft 126 with the optional cartridge motor 128. A controller 270further provides and operates the cartridge motor 128 to selectivelyrotate the occlusion shaft 126 (and thus the knob 120).

Various mechanisms (not shown) can be employed to effectuate a drivencoupling between the cartridge motor 128 and the occlusion shaft 126.For example, a drive gear can be coupled to the occlusion shaft 126, andthe cartridge motor 128 operably coupled to the drive gear. With thisbut one acceptable construction, operation of the cartridge motor 128causes the drive gear to rotate, that in turn rotates the occlusionshaft 126. Rotation of the occlusion shaft 126 rotates the knob 120 thatin turn effectuates a change in the radial position of the slide bodies72 a, 72 b as previously described, thus altering the level ofocclusion. Other constructions linking the cartridge motor 128 with theknob 120 and/or the cam body 150 are also acceptable.

The controller 270 is or includes a microprocessor or other computerdevice that is programmed to prompt and control operation of thecartridge motor 128. In this regard, the controller 270 can beprogrammed to control operation of the cartridge motor 128 as a functionof one or more input parameters. For example, the controller 270 caninclude, or be electronically linked to, an input device (e.g., touchscreen) at which a user enters a desired occlusion setting. In relatedembodiments, other selectable occlusion criteria can be utilized by thecontroller 252 in determining (and then effectuating) a desiredocclusion setting. For example, FIG. 8 provides, in block form,information that can be supplied to the controller 270 from the pumpingenvironment (e.g., a perfusion circuit), based upon which the controller270 effectuates operation of the cartridge motor 128. For example, inputfeedback information can include line pressure, motor torque, flow rate,etc. The user/perfusionist can prescribe the occlusion criteria suitedfor their particular practice. Regardless, as with the manual occlusionadjustment described above, automated occlusion adjustment provided bythe roller pump 20 can occur while the pump 20 continues to operate inthe pumping mode.

The roller pumps and related methods of use of the present disclosureprovide a marked improvement over previous designs. Occlusion adjustmentcan be performed with continuous operation of the roller pump in pumpinga fluid medium. Further, in some embodiments, automated occlusionadjustment is provided.

Although the present disclosure has been described with reference topreferred embodiments, workers skilled in the art will recognize thatchanges can be made in form and detail without departing from the spiritand scope of the present disclosure.

1-19. (canceled)
 20. A method of operating a roller pump is part of aperfusion circuit, the method comprising: loading a flexible tubing lineof the perfusion circuit to a roller pump, the roller pump including: adrive shaft defining a central axis, a motor coupled to the drive shaftfor rotating the drive shaft about the central axis, a roller headassembly including: a hub mounted to the drive shaft, a first slide bodyslidably connected to the hub such that the slide body rotates withrotation of the hub, a first roller rotatably coupled to the slide bodyopposite the drive shaft, a stator frame forming a raceway having aninner arcuate receiving surface, wherein the stator frame is associatedwith the roller head assembly to define an occlusion zone between theroller and the receiving surface. an occlusion adjustment assembly forslidably adjusting a radial position of the roller relative to thereceiving surface, the occlusion adjustment assembly including: anactuator knob, an actuating structure connected to the knob, a groundshaft supporting the actuator knob relative to the drive shaft, whereinthe actuating structure interfaces with the slide body to alter a radialposition of the slide body relative to the central axis with rotation ofthe knob; wherein the tubing line is disposed against the receivingsurface; operating the motor to cause the slide body and the roller torotate relative to the tubing line, including the roller located at afirst radial position relative to the receiving surface so as to occludethe tubing line at a first level of occlusion; and while continuing tooperate the motor, rotating the actuator knob to alter a radial locationof the roller to a second radial position different from the firstradial position to provide a second level of occlusion.
 21. The methodof claim 20, when the roller pump further includes a cartridge motorlinked to the occlusion adjustment assembly and a controller programmedto prompt operation of the cartridge motor, the method furthercomprising: receiving information at the controller indicative of anoperational parameter of the perfusion circuit; and automaticallyprompting the operation of the cartridge motor by the controller toeffectuate movement of the roller to a third radial position relative tothe receiving surface with continuous operation of the motor.